In the context of VTP, what is the primary goal when affecting tumor blood vessels?

The primary goal of affecting tumor blood vessels in the context of Vascular Targeted Photodynamic (VTP) therapy is to create ischemic conditions that lead to tumor cell death. VTP utilizes photosensitizers that target the vascular structures supplying blood to tumors. By selectively targeting these blood vessels and inducing damage through photodynamic therapy, the treatment can effectively disrupt blood flow. This disruption results in decreased oxygen and nutrient supply to the tumor, ultimately creating ischemia. The ischemic environment induces cellular stress, apoptosis, and necrosis within the tumor, leading to its destruction. This approach not only targets the tumor itself but also impacts the tumor's microenvironment, making it a compelling strategy for cancer treatment.

The other options don't align with the primary intent of VTP. Enhancing blood flow or increasing oxygen supply would generally not be beneficial, as tumors thrive on such conditions. Promoting the growth of tumor cells is contrary to the goal of any cancer treatment.