What does the term "vascular targeting" refer to in VTP?

The term "vascular targeting" in Vascular Targeted Photodynamic (VTP) refers specifically to the selection for and affectation of blood vessels that supply the tumor. This approach is crucial because the vascularization of a tumor is a key feature that can be exploited for therapeutic purposes. VTP aims to selectively target the abnormal blood vessels that are often associated with tumors. By doing so, it enhances the delivery of the photodynamic agent specifically to the tumor vasculature, leading to localized damage to the tumor while sparing surrounding normal tissues.

Focusing on the blood supply to the tumor allows for effective treatment modalities that can induce tumor cell death, utilize the unique properties of the tumor vasculature, and capitalize on the specific characteristics of the blood vessels that supply tumors. This selective targeting helps to maximize the treatment effect on the tumor while minimizing harm to healthy tissues, enabling precise and effective photodynamic therapy.